2WFR
Crystal structure of the N-terminal signalling domain of human Dhh with calcium
Summary for 2WFR
Entry DOI | 10.2210/pdb2wfr/pdb |
Related | 2WFQ 2WFT 2WFX 2WG3 2WG4 |
Descriptor | DESERT HEDGEHOG PROTEIN N-PRODUCT, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | lipoprotein, development, cell membrane, autocatalytic cleavage, signaling protein, disease mutation, hedgehog signalling, protease, membrane, secreted, palmitate, hydrolase, signal transduction, developmental protein |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 19186.77 |
Authors | Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (deposition date: 2009-04-14, release date: 2009-06-30, Last modification date: 2023-12-13) |
Primary citation | Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16:698-, 2009 Cited by PubMed: 19561611DOI: 10.1038/NSMB.1607 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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