2WFR

Crystal structure of the N-terminal signalling domain of human Dhh with calcium

2WFR の概要

• エントリーDOI: 10.2210/pdb2wfr/pdb
• 関連するPDBエントリー: 2WFQ 2WFT 2WFX 2WG3 2WG4
• 分子名称: DESERT HEDGEHOG PROTEIN N-PRODUCT, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: lipoprotein, development, cell membrane, autocatalytic cleavage, signaling protein, disease mutation, hedgehog signalling, protease, membrane, secreted, palmitate, hydrolase, signal transduction, developmental protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19186.77

構造登録者

Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C. (登録日: 2009-04-14, 公開日: 2009-06-30, 最終更新日: 2023-12-13)

• 主引用文献: Bishop, B.,Aricescu, A.R.,Harlos, K.,O'Callaghan, C.A.,Jones, E.Y.,Siebold, C.; Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip; Nat.Struct.Mol.Biol., 16:698-, 2009; PubMed: 19561611; DOI: 10.1038/NSMB.1607

実験手法

X-RAY DIFFRACTION (1.95 Å)