2WFG
Structure of the Candida albicans cytosolic leucyl-tRNA synthetase editing domain bound to a benzoxaborole-AMP adduct
Summary for 2WFG
Entry DOI | 10.2210/pdb2wfg/pdb |
Related | 2WFE |
Descriptor | CYTOSOLIC LEUCYL-TRNA SYNTHETASE, [(1S,3S,5R,6R,8R)-6-(6-AMINOPURIN-9-YL)-4'-ETHYLAMINO-3'-FLUORO-SPIRO[2,4,7-TRIOXA-3-BORANUIDABICYCLO[3.3.0]OCTANE-3,7'-8-OXA-7-BORANUIDABICYCLO[4.3.0]NONA-1,3,5-TRIENE]-8-YL]METHYL DIHYDROGEN PHOSPHATE (3 entities in total) |
Functional Keywords | ligase, leucyl-trna synthetase, editing domain, candida albicans, hydrolysis of mis-charged trnas, benzoxaborole, anti-fungal |
Biological source | CANDIDA ALBICANS |
Total number of polymer chains | 1 |
Total formula weight | 30019.81 |
Authors | Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. (deposition date: 2009-04-05, release date: 2009-05-19, Last modification date: 2024-05-08) |
Primary citation | Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles. J.Mol.Biol., 390:196-, 2009 Cited by PubMed: 19426743DOI: 10.1016/J.JMB.2009.04.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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