2WFD
Structure of the human cytosolic leucyl-tRNA synthetase editing domain
Summary for 2WFD
Entry DOI | 10.2210/pdb2wfd/pdb |
Descriptor | LEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (1 entity in total) |
Functional Keywords | aminoacyl-trna synthetase, phosphoprotein, editing domain, nucleotide-binding, hydrolysis of mis-charged trnas, protein biosynthesis, leucyl-trna synthetase, human, ligase, cytoplasm, atp-binding, polymorphism |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm (By similarity): Q9P2J5 |
Total number of polymer chains | 2 |
Total formula weight | 56943.39 |
Authors | Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. (deposition date: 2009-04-03, release date: 2009-05-19, Last modification date: 2011-07-13) |
Primary citation | Seiradake, E.,Mao, W.,Hernandez, V.,Baker, S.J.,Plattner, J.J.,Alley, M.R.K.,Cusack, S. Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles. J.Mol.Biol., 390:196-, 2009 Cited by PubMed: 19426743DOI: 10.1016/J.JMB.2009.04.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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