2WD1
Human c-Met Kinase in complex with azaindole inhibitor
Summary for 2WD1
Entry DOI | 10.2210/pdb2wd1/pdb |
Related | 1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2CEW 2G15 2UZX 2UZY |
Descriptor | HEPATOCYTE GROWTH FACTOR RECEPTOR, 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE, GAMMA-BUTYROLACTONE, ... (4 entities in total) |
Functional Keywords | human kinase, c-met, azaindole, inhibitor, transferase, kinase, nucleotide-binding, atp-binding, tyrosine-protein kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 33566.92 |
Authors | Porter, J.,Lumb, S.,Franklin, R.J.,Gascon-Simorte, J.M.,Calmiano, M.,Le Riche, K.,Lallemand, B.,Keyaerts, J.,Edwards, H.,Maloney, A.,Delgado, J.,King, L.,Foley, A.,Lecomte, F.,Reuberson, J.,Meier, C.,Batchelor, M. (deposition date: 2009-03-19, release date: 2009-04-28, Last modification date: 2024-05-08) |
Primary citation | Porter, J.,Lumb, S.,Franklin, R.J.,Gascon-Simorte, J.M.,Calmiano, M.,Riche, K.L.,Lallemand, B.,Keyaerts, J.,Edwards, H.,Maloney, A.,Delgado, J.,King, L.,Foley, A.,Lecomte, F.,Reuberson, J.,Meier, C.,Batchelor, M. Discovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase. Bioorg.Med.Chem.Lett., 19:2780-, 2009 Cited by PubMed: 19369077DOI: 10.1016/J.BMCL.2009.03.110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report