2WCN

Solution structure of an LNA-modified quadruplex

2WCN の概要

• エントリーDOI: 10.2210/pdb2wcn/pdb
• 分子名称: DNA (5'-D(*DGP*LCG*DGP*LCG*DTP*DTP*DTP *DTP*DGP*LCG*DGP*LCG)-3') (1 entity in total)
• 機能のキーワード: lna, quadruplex, folding topology, dna
• 由来する生物種: OXYTRICHA NOVA
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7835.00

構造登録者

Nielsen, J.T.,Arar, K.,Petersen, M. (登録日: 2009-03-12, 公開日: 2009-11-24, 最終更新日: 2024-05-15)

主引用文献

Nielsen, J.T.,Arar, K.,Petersen, M.
Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology.
Angew.Chem.Int.Ed.Engl., 48:3099-, 2009

PubMed Abstract: Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology.

PubMed: 19308940
DOI: 10.1002/ANIE.200806244

実験手法

SOLUTION NMR