2WCG

X-ray structure of acid-beta-glucosidase with N-octyl(cyclic guanidine)-nojirimycin in the active site

2WCG の概要

• エントリーDOI: 10.2210/pdb2wcg/pdb
• 分子名称: GLUCOSYLCERAMIDASE, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose, ... (7 entities in total)
• 機能のキーワード: lipid metabolism, glucocerebrosidase, membrane, lysosome, hydrolase, glucosidase, glycoprotein, gaucher disease, sphingolipid metabolism
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116536.46

構造登録者

Brumshtein, B.,Aguilar, M.,Garcia-Moreno, M.I.,Mellet, C.O.,Garcia-Fernandez, J.M.,Silman, I.,Shaaltiel, Y.,Aviezer, D.,Sussman, J.L.,Futerman, A.H. (登録日: 2009-03-12, 公開日: 2009-11-24, 最終更新日: 2023-12-13)

• 主引用文献: Brumshtein, B.,Aguilar-Moncayo, M.,Garcia-Moreno, M.I.,Ortiz Mellet, C.,Garcia Fernandez, J.M.,Silman, I.,Shaaltiel, Y.,Aviezer, D.,Sussman, J.L.,Futerman, A.H.; 6-Amino-6-Deoxy-5,6-Di-N-(N'-Octyliminomethylidene)Nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid Beta-Glucosidase.; Chembiochem, 10:1480-, 2009; PubMed: 19437524; DOI: 10.1002/CBIC.200900142

実験手法

X-RAY DIFFRACTION (2.3 Å)