2WBM

Crystal structure of mthSBDS, the homologue of the Shwachman-Bodian- Diamond syndrome protein in the euriarchaeon Methanothermobacter thermautotrophicus

2WBM の概要

• エントリーDOI: 10.2210/pdb2wbm/pdb
• 分子名称: RIBOSOME MATURATION PROTEIN SDO1 HOMOLOG, GLYCEROL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: shwachman-bodian-diamond syndrome protein, ribosome binding, conformational flexibility, rna-binding protein, rna binding protein
• 由来する生物種: METHANOTHERMOBACTER THERMAUTOTROPHICUS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57630.94

構造登録者

Ng, C.L.,Isupov, M.N.,Lebedev, A.A.,Ortiz-Lombardia, M.,Antson, A.A. (登録日: 2009-03-02, 公開日: 2009-06-02, 最終更新日: 2023-12-13)

主引用文献

Ng, C.L.,Waterman, D.G.,Koonin, E.V.,Walters, A.D.,Chong, J.P.,Isupov, M.N.,Lebedev, A.A.,Bunka, D.H.,Stockley, P.G.,Ortiz-Lombardia, M.,Antson, A.A.
Conformational Flexibility and Molecular Interactions of an Archaeal Homologue of the Shwachman-Bodian-Diamond Syndrome Protein.
Bmc Struct.Biol., 9:32-, 2009

PubMed Abstract: Defects in the human Shwachman-Bodian-Diamond syndrome (SBDS) protein-coding gene lead to the autosomal recessive disorder characterised by bone marrow dysfunction, exocrine pancreatic insufficiency and skeletal abnormalities. This protein is highly conserved in eukaryotes and archaea but is not found in bacteria. Although genomic and biophysical studies have suggested involvement of this protein in RNA metabolism and in ribosome biogenesis, its interacting partners remain largely unknown.

PubMed: 19454024
DOI: 10.1186/1472-6807-9-32

実験手法

X-RAY DIFFRACTION (1.75 Å)