2W93
Crystal structure of the Saccharomyces cerevisiae pyruvate decarboxylase variant E477Q in complex with the surrogate pyruvamide
Summary for 2W93
| Entry DOI | 10.2210/pdb2w93/pdb |
| Related | 1PVD 1PYD 1QPB 2VK1 2VK8 |
| Descriptor | PYRUVATE DECARBOXYLASE ISOZYME 1, THIAMINE DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
| Functional Keywords | substrate activation, substrate regulation, lyase, nucleus, cytoplasm, magnesium, acetylation, phosphoprotein, allosteric enzyme, thiamine pyrophosphate, phenylalanine catabolism, tryptophan catabolism, pyruvate decarboxylase, branched-chain amino acid catabolism, metal-binding, thiohemiketal, decarboxylase |
| Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
| Total number of polymer chains | 4 |
| Total formula weight | 248931.42 |
| Authors | Kutter, S.,Weiss, M.S.,Konig, S. (deposition date: 2009-01-21, release date: 2009-02-03, Last modification date: 2023-12-13) |
| Primary citation | Konig, S.,Spinka, M.,Kutter, S. Allosteric Activation of Pyruvate Decarboxylases. A Never-Ending Story. J.Mol.Catal., B Enzym., 61:100-, 2014 Cited by DOI: 10.1016/J.MOLCATB.2009.02.010PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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