2W59

STRUCTURE OF AN AVIAN IGY-FC 3-4 FRAGMENT

2W59 の概要

• エントリーDOI: 10.2210/pdb2w59/pdb
• 分子名称: IGY FCU3-4, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: immunoglobulin, avian, igy fc, immune system
• 由来する生物種: GALLUS GALLUS (CHICKEN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 52711.34

構造登録者

Fabiane, S.M.,Taylor, A.I.,Sutton, B.J.,Calvert, R.A. (登録日: 2008-12-08, 公開日: 2009-01-13, 最終更新日: 2024-10-16)

主引用文献

Taylor, A.I.,Fabiane, S.M.,Sutton, B.J.,Calvert, R.A.
The Crystal Structure of an Avian Igy-Fc Fragment Reveals Conservation with Both Mammalian Igg and Ige.
Biochemistry, 48:558-, 2009

PubMed Abstract: Avian IgY is closely related to an ancestor of both mammalian IgG and IgE and thus provides insights into the evolution of antibody structure and function. A recombinant fragment of IgY-Fc consisting of a dimer of the Cupsilon3 and Cupsilon4 domains, Fcupsilon3-4, was expressed and crystallized and its X-ray structure determined to 1.75 A resolution. Fcupsilon3-4 is the only nonmammalian Fc fragment structure determined to date and provides the first structural evidence for an ancient origin of antibody architecture. The Fcupsilon3-4 structure reveals features common to both IgE-Fc and IgG-Fc, and the implications for IgY binding to its receptor are discussed.

PubMed: 19115948
DOI: 10.1021/BI8019993

実験手法

X-RAY DIFFRACTION (1.75 Å)