2W3V

MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM

Summary for 2W3V

• Entry DOI: 10.2210/pdb2w3v/pdb
• Related: 2W3W
• Descriptor: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... (4 entities in total)
• Functional Keywords: nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
• Biological source: Mycobacterium avium
• Total number of polymer chains: 1
• Total formula weight: 19487.56

Authors

Leung, A.K.W.,Reynolds, R.C.,Borhani, D.W. (deposition date: 2008-11-16, release date: 2009-11-17, Last modification date: 2023-12-13)

• Primary citation: Leung, A.K.W.,Ross, L.J.,Zywno-Van Ginkel, S.,Reynolds, R.C.,Seitz, L.E.,Pathak, V.,Barrow, W.W.,White, E.L.,Suling, W.J.,Piper, J.R.,Borhani, D.W.; Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate; To be Published,

Experimental method

X-RAY DIFFRACTION (1.89 Å)