2W3V

MYCOBACTERIUM AVIUM DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND TRIMETHOPRIM

2W3V の概要

• エントリーDOI: 10.2210/pdb2w3v/pdb
• 関連するPDBエントリー: 2W3W
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... (4 entities in total)
• 機能のキーワード: nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
• 由来する生物種: Mycobacterium avium
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19487.56

構造登録者

Leung, A.K.W.,Reynolds, R.C.,Borhani, D.W. (登録日: 2008-11-16, 公開日: 2009-11-17, 最終更新日: 2023-12-13)

• 主引用文献: Leung, A.K.W.,Ross, L.J.,Zywno-Van Ginkel, S.,Reynolds, R.C.,Seitz, L.E.,Pathak, V.,Barrow, W.W.,White, E.L.,Suling, W.J.,Piper, J.R.,Borhani, D.W.; Structural Basis for Selective Inhibition of Mycobacterium Avium Dihydrofolate Reductase by a Lipophilic Antifolate; To be Published,

実験手法

X-RAY DIFFRACTION (1.89 Å)