2W2D
Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A
Summary for 2W2D
Entry DOI | 10.2210/pdb2w2d/pdb |
Descriptor | BOTULINUM NEUROTOXIN A LIGHT CHAIN, BOTULINUM NEUROTOXIN A HEAVY CHAIN, SULFATE ION, ... (8 entities in total) |
Functional Keywords | metalloprotease, membrane domain, protein engineering, neurotoxin, metal-binding, transmembrane, pharmaceutical, hydrolase, zinc protease, mixed alpha and beta, bont, membrane, secreted, protease |
Biological source | CLOSTRIDIUM BOTULINUM More |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 |
Total number of polymer chains | 4 |
Total formula weight | 203251.05 |
Authors | Masuyer, G.,Thiyagarajan, N.,James, P.L.,Marks, P.M.H.,Chaddock, J.A.,Acharya, K.R. (deposition date: 2008-10-29, release date: 2009-03-24, Last modification date: 2022-05-04) |
Primary citation | Masuyer, G.,Thiyagarajan, N.,James, P.L.,Marks, P.M.H.,Chaddock, J.A.,Acharya, K.R. Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A. Biochem.Biophys.Res.Commun., 381:50-, 2009 Cited by PubMed: 19351593DOI: 10.1016/J.BBRC.2009.02.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.59 Å) |
Structure validation
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