2W2D

Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A

2W2D の概要

• エントリーDOI: 10.2210/pdb2w2d/pdb
• 分子名称: BOTULINUM NEUROTOXIN A LIGHT CHAIN, BOTULINUM NEUROTOXIN A HEAVY CHAIN, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: metalloprotease, membrane domain, protein engineering, neurotoxin, metal-binding, transmembrane, pharmaceutical, hydrolase, zinc protease, mixed alpha and beta, bont, membrane, secreted, protease
• 由来する生物種: CLOSTRIDIUM BOTULINUM; 詳細
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 203251.05

構造登録者

Masuyer, G.,Thiyagarajan, N.,James, P.L.,Marks, P.M.H.,Chaddock, J.A.,Acharya, K.R. (登録日: 2008-10-29, 公開日: 2009-03-24, 最終更新日: 2022-05-04)

• 主引用文献: Masuyer, G.,Thiyagarajan, N.,James, P.L.,Marks, P.M.H.,Chaddock, J.A.,Acharya, K.R.; Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A.; Biochem.Biophys.Res.Commun., 381:50-, 2009; PubMed: 19351593; DOI: 10.1016/J.BBRC.2009.02.003

実験手法

X-RAY DIFFRACTION (2.59 Å)