2W18

Crystal structure of the C-terminal WD40 domain of human PALB2

2W18 の概要

• エントリーDOI: 10.2210/pdb2w18/pdb
• 分子名称: PARTNER AND LOCALIZER OF BRCA2, GLYCEROL (3 entities in total)
• 機能のキーワード: fanconi anemia, homologous recomination, polymorphism, phosphoprotein, beta-propeller, wd40, fanc-n, nucleus, wd repeat, coiled coil, nuclear protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: Q86YC2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39624.26

構造登録者

Oliver, A.W.,Pearl, L.H. (登録日: 2008-10-15, 公開日: 2009-07-28, 最終更新日: 2024-05-08)

主引用文献

Oliver, A.W.,Swift, S.,Lord, C.J.,Ashworth, A.,Pearl, L.H.
Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10:990-, 2009

PubMed Abstract: The breast cancer 2, early onset protein (BRCA2) is central to the repair of DNA damage by homologous recombination. BRCA2 recruits the recombinase RAD51 to sites of damage, regulates its assembly into nucleoprotein filaments and thereby promotes homologous recombination. Localization of BRCA2 to nuclear foci requires its association with the partner and localizer of BRCA2 (PALB2), mutations in which are associated with cancer predisposition, as well as subtype N of Fanconi anaemia. We have determined the structure of the PALB2 carboxy-terminal beta-propeller domain in complex with a BRCA2 peptide. The structure shows the molecular determinants of this important protein-protein interaction and explains the effects of both cancer-associated truncating mutants in PALB2 and missense mutations in the amino-terminal region of BRCA2.

PubMed: 19609323
DOI: 10.1038/EMBOR.2009.126

実験手法

X-RAY DIFFRACTION (1.9 Å)