2W13

High-resolution crystal structure of the P-I snake venom metalloproteinase BaP1 in complex with a peptidomimetic: insights into inhibitor binding

2W13 の概要

• エントリーDOI: 10.2210/pdb2w13/pdb
• 関連するPDBエントリー: 1ND1 2W12 2W14 2W15
• 分子名称: ZINC METALLOPROTEINASE BAP1, ZINC ION, (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE, ... (6 entities in total)
• 機能のキーワード: hydrolase inhibitor complex, metzincin, chemotaxis, adamalysins, endopeptidase, metal-binding, zinc-depending, metalloprotease, metalloproteinase-inhibitor complex, zinc, toxin, secreted, protease, hydrolase, p-i snake venom metalloproteinase, alpha-beta proteins, matrixmetalloproteinase, tumor necrosis factor alpha converting enzyme, pyrrolidone carboxylic acid, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: BOTHROPS ASPER (TERCIOPELO)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23594.00

構造登録者

Lingott, T.J.,Schleberger, C.,Gutierrez, J.M.,Merfort, I. (登録日: 2008-10-14, 公開日: 2009-06-16, 最終更新日: 2023-12-13)

• 主引用文献: Lingott, T.J.,Schleberger, C.,Gutierrez, J.M.,Merfort, I.; High-Resolution Crystal Structure of the Snake Venom Metalloproteinase Bap1 Complexed with a Peptidomimetic: Insight Into Inhibitor Binding.; Biochemistry, 48:6166-, 2009; PubMed: 19485419; DOI: 10.1021/BI9002315

実験手法

X-RAY DIFFRACTION (1.14 Å)