2W0J

Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor

2W0J の概要

• エントリーDOI: 10.2210/pdb2w0j/pdb
• 関連するPDBエントリー: 1GXC 2CN5 2CN8
• 分子名称: SERINE/THREONINE-PROTEIN KINASE CHK2, 4,4'-DIACETYLDIPHENYLUREA-BIS(GUANYLHYDRAZONE), NITRATE ION, ... (4 entities in total)
• 機能のキーワード: chk2 inhibitor, oncology, kinase, structure-assisted drug design, transferase, nucleotide-binding, li-fraumeni syndrome, serine/threonine-protein kinase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37032.70

構造登録者

Lountos, G.T.,Tropea, J.E.,Zhang, D.,Jobson, A.G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S. (登録日: 2008-08-18, 公開日: 2009-02-10, 最終更新日: 2023-12-13)

• 主引用文献: Lountos, G.T.,Tropea, J.E.,Zhang, D.,Jobson, A.G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S.; Crystal Structure of Checkpoint Kinase 2 in Complex with Nsc 109555, a Potent and Selective Inhibitor; Protein Sci., 18:92-, 2009; PubMed: 19177354; DOI: 10.1002/PRO.16

実験手法

X-RAY DIFFRACTION (2.05 Å)