2VZ7

Crystal structure of the YC-17-bound PikC D50N mutant

Replaces:  2VSJ

Summary for 2VZ7

• Entry DOI: 10.2210/pdb2vz7/pdb
• Related: 2BVJ 2C6H 2C7X 2CA0 2CD8
• Descriptor: CYTOCHROME P450 MONOOXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE, ... (4 entities in total)
• Functional Keywords: oxidoreductase, antibiotic biosynthesis, pikc, iron, heme, cyp107l1, monooxygenase, macrolide monooxygenase, metal-binding, cytochrome p450
• Biological source: STREPTOMYCES VENEZUELAE
• Total number of polymer chains: 2
• Total formula weight: 98675.71

Authors

Li, S.,Sherman, D.H.,Podust, L.M. (deposition date: 2008-07-30, release date: 2008-08-12, Last modification date: 2023-12-13)

• Primary citation: Li, S.,Ouellet, H.,Sherman, D.H.,Podust, L.M.; Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae.; J.Biol.Chem., 284:5723-, 2009; PubMed: 19124459; DOI: 10.1074/JBC.M807592200

Experimental method

X-RAY DIFFRACTION (3.2 Å)