2VWU

ephB4 kinase domain inhibitor complex

2VWU の概要

• エントリーDOI: 10.2210/pdb2vwu/pdb
• 関連するPDBエントリー: 2BBA 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1
• 分子名称: EPHRIN TYPE-B RECEPTOR 4, N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine (3 entities in total)
• 機能のキーワード: tyrosine-protein kinase, receptor tyrosine kinase, kinase, mutant, membrane, receptor, transferase, atp-binding, polymorphism, glycoprotein, transmembrane, phosphoprotein, unphosphorylated, nucleotide-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34405.76

構造登録者

Read, J.,Brassington, C.A.,Green, I.,McCall, E.J.,Valentine, A.L.,Barratt, D.,Rowsell, S.,Packer, M.,McAlister, M. (登録日: 2008-06-27, 公開日: 2008-07-08, 最終更新日: 2023-12-13)

• 主引用文献: Bardelle, C.,Cross, D.,Davenport, S.,Kettle, J.G.,Ko, E.J.,Leach, A.G.,Mortlock, A.,Read, J.,Roberts, N.J.,Robins, P.,Williams, E.J.; Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines; Bioorg.Med.Chem.Lett., 18:2776-, 2008; PubMed: 18434142; DOI: 10.1016/J.BMCL.2008.04.015

実験手法

X-RAY DIFFRACTION (2 Å)