2VU9

CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A BINDING DOMAIN IN COMPLEX WITH GT1B

2VU9 の概要

• エントリーDOI: 10.2210/pdb2vu9/pdb
• 関連するPDBエントリー: 1UEE 2VUA 3BTA
• 分子名称: BOTULINUM NEUROTOXIN A HEAVY CHAIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, metalloprotease, neurotoxin, ganglioside, metal-binding, toxin, protease, membrane, receptor, secreted
• 由来する生物種: CLOSTRIDIUM BOTULINUM
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53027.84

構造登録者

Stenmark, P.,Dupuy, J.,Stevens, R.C. (登録日: 2008-05-22, 公開日: 2008-08-26, 最終更新日: 2023-12-13)

• 主引用文献: Stenmark, P.,Dupuy, J.,Imamura, A.,Kiso, M.,Stevens, R.C.; Crystal Structure of Botulinum Neurotoxin Type a in Complex with the Cell Surface Co-Receptor Gt1B- Insight Into the Toxin-Neuron Interaction.; Plos Pathog., 4:E129-, 2008; PubMed: 18704164; DOI: 10.1371/JOURNAL.PPAT.1000129

実験手法

X-RAY DIFFRACTION (1.6 Å)