2VTE

Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor

2VTE の概要

• エントリーDOI: 10.2210/pdb2vte/pdb
• 関連するPDBエントリー: 1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTD 3UAG 4UAG
• 分子名称: UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-({7-[(4-cyanobenzyl)oxy]naphthalen-2-yl}sulfonyl)-D-glutamic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: murd-inhibitor complex, peptidoglycan synthesis, nucleotide-binding, sulfonamide inhibitor, murd ligase, atp-binding, cell division, ligase, cytoplasm, cell shape, cell cycle, cell wall biogenesis/degradation
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48543.94

構造登録者

Humljan, J.,Kotnik, M.,Contreras-Martel, C.,Blanot, D.,Urleb, U.,Dessen, A.,Solmajer, T.,Gobec, S. (登録日: 2008-05-14, 公開日: 2008-11-25, 最終更新日: 2023-12-13)

• 主引用文献: Humljan, J.,Kotnik, M.,Contreras-Martel, C.,Blanot, D.,Urleb, U.,Dessen, A.,Solmajer, T.,Gobec, S.; Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme.; J. Med. Chem., 51:7486-7494, 2008; PubMed: 19007109; DOI: 10.1021/jm800762u

実験手法

X-RAY DIFFRACTION (2.2 Å)