2VTD
Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor
Summary for 2VTD
Entry DOI | 10.2210/pdb2vtd/pdb |
Related | 1E0D 1EEH 1UAG 2JFF 2JFG 2JFH 2UAG 2UUO 2UUP 2VTE 3UAG 4UAG |
Descriptor | UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE, N-({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)-D-GLUTAMIC ACID, SULFATE ION, ... (4 entities in total) |
Functional Keywords | murd-inhibitor complex, peptidoglycan synthesis, nucleotide-binding, sulfonamide inhibitor, murd ligase, atp-binding, cell division, ligase, cytoplasm, cell shape, cell cycle, cell wall biogenesis/degradation |
Biological source | ESCHERICHIA COLI |
Total number of polymer chains | 1 |
Total formula weight | 48561.93 |
Authors | Humljan, J.,Kotnik, M.,Contreras-Martel, C.,Blanot, D.,Urleb, U.,Dessen, A.,Solmajer, T.,Gobec, S. (deposition date: 2008-05-14, release date: 2008-11-25, Last modification date: 2023-12-13) |
Primary citation | Humljan, J.,Kotnik, M.,Contreras-Martel, C.,Blanot, D.,Urleb, U.,Dessen, A.,Solmajer, T.,Gobec, S. Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51:7486-7494, 2008 Cited by PubMed: 19007109DOI: 10.1021/jm800762u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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