2VT0

X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells

2VT0 の概要

• エントリーDOI: 10.2210/pdb2vt0/pdb
• 分子名称: GLUCOSYLCERAMIDASE, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hydrolase, alternative initiation, sphingolipid metabolism, israel structural proteomics center, disease mutation, glucocerebrosidase, pharmaceutical, gaucher disease, lipid metabolism, glucosidase, glycosidase, polymorphism, glycoprotein, ispc, membrane, cerezyme, lysosome, structural genomics, alternative splicing
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115802.74

構造登録者

Brumshtein, B.,Greenblatt, H.M.,Shaaltiel, Y.,Aviezer, D.,Silman, I.,Futerman, A.H.,Sussman, J.L. (登録日: 2008-05-03, 公開日: 2008-09-23, 最終更新日: 2023-12-13)

• 主引用文献: Kacher, Y.,Brumshtein, B.,Boldin-Adamsky, S.,Toker, L.,Shainskaya, A.,Silman, I.,Sussman, J.L.,Futerman, A.H.; Acid Beta-Glucosidase: Insights from Structural Analysis and Relevance to Gaucher Disease Therapy.; Biol.Chem., 389:1361-, 2008; PubMed: 18783340; DOI: 10.1515/BC.2008.163

実験手法

X-RAY DIFFRACTION (2.15 Å)