2VSN

Structure and topological arrangement of an O-GlcNAc transferase homolog: insight into molecular control of intracellular glycosylation

2VSN の概要

• エントリーDOI: 10.2210/pdb2vsn/pdb
• 分子名称: XCOGT, URIDINE-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: glycosyl transferase, n- acetylglucosamine, tpr, ogt, glcnac, o-glycosylation, transferase
• 由来する生物種: XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123485.46

構造登録者

Martinez-Fleites, C.,Macauley, M.S.,He, Y.,Shen, D.,Vocadlo, D.,Davies, G.J. (登録日: 2008-04-28, 公開日: 2008-06-10, 最終更新日: 2024-05-08)

主引用文献

Martinez-Fleites, C.,Macauley, M.S.,He, Y.,Shen, D.L.,Vocadlo, D.J.,Davies, G.J.
Structure of an O-Glcnac Transferase Homolog Provides Insight Into Intracellular Glycosylation.
Nat.Struct.Mol.Biol., 15:764-, 2008

PubMed Abstract: N-Acetylglucosamine (O-GlcNAc) modification of proteins provides a mechanism for the control of diverse cellular processes through a dynamic interplay with phosphorylation. UDP-GlcNAc:polypeptidyl transferase (OGT) catalyzes O-GlcNAc addition. The structure of an intact OGT homolog and kinetic analysis of human OGT variants reveal a contiguous superhelical groove that directs substrates to the active site.

PubMed: 18536723
DOI: 10.1038/NSMB.1443

実験手法

X-RAY DIFFRACTION (2.75 Å)