2VRX

Structure of Aurora B kinase in complex with ZM447439

2VRX の概要

• エントリーDOI: 10.2210/pdb2vrx/pdb
• 関連するPDBエントリー: 2BFX 2BFY 2VGO 2VGP
• 分子名称: SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}phenyl)benzamide, ... (4 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, kinase, nucleus, mitosis, magnesium, cell cycle/transferase, centromere, microtubule, atp-binding, transferase, anti-cancer drug target, phosphoprotein, protein kinase, nucleotide-binding, coiled coil, cell division, metal-binding, cell cycle-transferase complex
• 由来する生物種: XENOPUS LAEVIS (AFRICAN CLAWED FROG); 詳細
• 細胞内の位置: Nucleus: Q6DE08; Chromosome, centromere: O13024
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78284.39

構造登録者

Girdler, F.,Sessa, F.,Patercoli, S.,Villa, F.,Ridgway, E.,Musacchio, A.,Taylor, S.S. (登録日: 2008-04-16, 公開日: 2008-07-01, 最終更新日: 2011-07-13)

• 主引用文献: Girdler, F.,Sessa, F.,Patercoli, S.,Villa, F.,Musacchio, A.,Taylor, S.S.; Molecular Basis of Drug Resistance in Aurora Kinases.; Chem.Biol., 15:552-, 2008; PubMed: 18559266; DOI: 10.1016/J.CHEMBIOL.2008.04.013

実験手法

X-RAY DIFFRACTION (1.86 Å)