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2VQ1

anti trimeric Lewis X Fab54-5C10-A

2VQ1 の概要
エントリーDOI10.2210/pdb2vq1/pdb
分子名称IGKV1-117 PROTEIN, ANTI-HUMAN FC GAMMA RECEPTOR III 3G8 GAMMA HEAVY CHAIN VARIABLE REGION, GLYCINE, ... (6 entities in total)
機能のキーワードmonoclonal antibody, receptor, diagnosis, schistosomiasis, carbohydrate recognition, immune system
由来する生物種MUS MUSCULUS (MOUSE)
詳細
タンパク質・核酸の鎖数4
化学式量合計95700.76
構造登録者
de Geus, D.C.,van Roon, A.M.M.,Thomassen, E.A.J.,Hokke, C.H.,Deelder, A.M.,Abrahams, J.P. (登録日: 2008-03-10, 公開日: 2009-01-27, 最終更新日: 2024-11-20)
主引用文献De Geus, D.C.,Van Roon, A.M.M.,Thomassen, E.A.J.,Hokke, C.H.,Deelder, A.M.,Abrahams, J.P.
Characterization of a Diagnostic Fab Fragment Binding Trimeric Lewis X.
Proteins, 76:439-, 2009
Cited by
PubMed Abstract: Lewis X trisaccharides normally function as essential cell-cell interaction mediators. However, oligomers of Lewis X trisaccharides expressed by the parasite Schistosoma mansoni seem to be related to its evasion of the immune response of its human host. Here we show that monoclonal antibody 54-5C10-A, which is used to diagnose schistosomiasis in humans, interacts with oligomers of at least three Lewis X trisaccharides, but not with monomeric Lewis X. We describe the sequence and the 2.5 A crystal structure of its Fab fragment and infer a possible mode of binding of the polymeric Lewis X from docking studies. Our studies indicate a radically different mode of binding compared to Fab 291-2G3-A, which is specific for monomeric Lewis X, thus providing a structural explanation of the diagnostic success of 54-5C10-A.
PubMed: 19173313
DOI: 10.1002/PROT.22356
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.5 Å)
構造検証レポート
Validation report summary of 2vq1
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-09に公開中

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