2VPJ

Crystal structure of the Kelch domain of human KLHL12

2VPJ の概要

• エントリーDOI: 10.2210/pdb2vpj/pdb
• 分子名称: KELCH-LIKE PROTEIN 12, ACETATE ION (3 entities in total)
• 機能のキーワード: adaptor protein, wnt signaling pathway, protein-binding, ubiquitin degradation, ubl conjugation pathway, cul3, kelch repeat, phosphoprotein, wnt signalling, protein binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasmic vesicle, COPII-coated vesicle : Q53G59
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33023.97

構造登録者

Keates, T.,Pike, A.C.W.,Bullock, A.N.,Salah, E.,Filippakopoulos, P.,Roos, A.K.,von Delft, F.,Savitsky, P.,Weigelt, J.,Edwards, A.,Arrowsmith, C.H.,Bountra, C.,Knapp, S. (登録日: 2008-02-29, 公開日: 2008-03-18, 最終更新日: 2023-12-13)

• 主引用文献: Canning, P.,Cooper, C.D.O.,Krojer, T.,Murray, J.W.,Pike, A.C.W.,Chaikuad, A.,Keates, T.,Thangaratnarajah, C.,Hojzan, V.,Marsden, B.D.,Gileadi, O.,Knapp, S.,von Delft, F.,Bullock, A.N.; Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.; J.Biol.Chem., 288:7803-, 2013; PubMed: 23349464; DOI: 10.1074/JBC.M112.437996

実験手法

X-RAY DIFFRACTION (1.85 Å)