2VK1

Crystal structure of the Saccharomyces cerevisiae pyruvate decarboxylase variant D28A in complex with its substrate

2VK1 の概要

• エントリーDOI: 10.2210/pdb2vk1/pdb
• 関連するPDBエントリー: 1PVD 1PYD 1QPB
• 分子名称: PYRUVATE DECARBOXYLASE ISOZYME 1, THIAMINE DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: asymmetric active sites, phenylalanine catabolism, tryptophan catabolism, thiamine pyrophosphate, dimer of dimers, phosphorylation, allosteric enzyme, tdp, tpp, lyase, nucleus, pyruvate, cytoplasm, branched-chain amino acid catabolism, substrate activation, thiamine diphosphate, magnesium, acetylation, metal-binding, decarboxylase
• 由来する生物種: SACCHAROMYCES CEREVISIAE (YEAST)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 248554.96

構造登録者

Kutter, S.,Weik, M.,Weiss, M.S.,Konig, S. (登録日: 2007-12-16, 公開日: 2009-01-27, 最終更新日: 2023-12-13)

• 主引用文献: Kutter, S.,Weiss, M.S.,Wille, G.,Golbik, R.,Spinka, M.,Konig, S.; Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.; J.Biol.Chem., 284:12136-, 2009; PubMed: 19246454; DOI: 10.1074/JBC.M806228200

実験手法

X-RAY DIFFRACTION (1.71 Å)