2VJY

Pyruvate decarboxylase from Kluyveromyces lactis in complex with the substrate analogue methyl acetylphosphonate

2VJY の概要

• エントリーDOI: 10.2210/pdb2vjy/pdb
• 関連するPDBエントリー: 2G1I 2VK4
• 分子名称: PYRUVATE DECARBOXYLASE, THIAMINE DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: metal-binding, decarboxylase, dimer of dimers, methylacetylphosphonate, methyl acetylphosphonate, substrate activation, thiamine diphosphate, thiamine pyrophosphate, asymmetric active sites, map, lyase, pyruvate, magnesium, flavoprotein
• 由来する生物種: KLUYVEROMYCES LACTIS (YEAST)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 250200.30

構造登録者

Kutter, S.,Wille, G.,Weiss, M.S.,Konig, S. (登録日: 2007-12-14, 公開日: 2009-01-27, 最終更新日: 2023-12-13)

• 主引用文献: Kutter, S.,Weiss, M.S.,Wille, G.,Golbik, R.,Spinka, M.,Konig, S.; Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.; J.Biol.Chem., 284:12136-, 2009; PubMed: 19246454; DOI: 10.1074/JBC.M806228200

実験手法

X-RAY DIFFRACTION (2.3 Å)