2VJF

Crystal Structure of the MDM2-MDMX RING Domain Heterodimer

2VJF の概要

• エントリーDOI: 10.2210/pdb2vjf/pdb
• 関連するPDBエントリー: 1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2CR8 2HDP 2VJE
• 分子名称: E3 UBIQUITIN-PROTEIN LIGASE MDM2, MDM4 PROTEIN, ZINC ION, ... (5 entities in total)
• 機能のキーワード: proto-oncogene, phosphorylation, alternative splicing, host-virus interaction, ubl conjugation pathway, zinc-finger, polymorphism, metal-binding, mdm, zinc, ring, ligase, nucleus, cytoplasm
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 29054.78

構造登録者

Mace, P.D.,Linke, K.,Smith, C.A.,Day, C.L. (登録日: 2007-12-10, 公開日: 2008-05-13, 最終更新日: 2024-05-08)

• 主引用文献: Linke, K.,Mace, P.D.,Smith, C.A.,Vaux, D.L.,Silke, J.,Day, C.L.; Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans.; Cell Death Differ., 15:841-, 2008; PubMed: 18219319; DOI: 10.1038/SJ.CDD.4402309

実験手法

X-RAY DIFFRACTION (2.3 Å)