2VIM
X-ray structure of Fasciola hepatica thioredoxin
Summary for 2VIM
| Entry DOI | 10.2210/pdb2vim/pdb |
| Descriptor | THIOREDOXIN (2 entities in total) |
| Functional Keywords | thioredoxin, trx, thioredoxin fold, oxidoreductase |
| Biological source | FASCIOLA HEPATICA (LIVER FLUKE) |
| Total number of polymer chains | 1 |
| Total formula weight | 11700.44 |
| Authors | Line, K.,Isupov, M.N.,Garcia-Rodriguez, E.,Maggioli, G.,Parra, F.,Littlechild, J.A. (deposition date: 2007-12-05, release date: 2008-07-29, Last modification date: 2024-10-16) |
| Primary citation | Line, K.,Isupov, M.N.,Garcia-Rodriguez, E.,Maggioli, G.,Parra, F.,Littlechild, J.A. The Fasciola Hepatica Thioredoxin: High Resolution Structure Reveals Two Oxidation States. Mol.Biochem.Parasitol., 161:44-, 2008 Cited by PubMed Abstract: The Fasciola hepatica thioredoxin protein structure has been determined to 1.45A resolution. This is the first example of a single crystal structure to show the active site cysteine residues in both the reduced and disulfide oxidised form. Consistent with this observation the process of oxidation appears to require very little rearrangement of the surrounding protein structure. The F. hepatica thioredoxin structure has been compared to other thioredoxin protein structures already known and is found to be highly conserved. The F. hepatica protein is most similar to that of the thioredoxin from its human and animal hosts but it resembles other parasitic thioredoxins with regard to having no additional cysteine residues and is therefore not regulated by transient disulfide bond formation as proposed for thioredoxins from higher eukaryotic species. PubMed: 18620002DOI: 10.1016/J.MOLBIOPARA.2008.06.009 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.38 Å) |
Structure validation
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