2VBQ

Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.

2VBQ の概要

• エントリーDOI: 10.2210/pdb2vbq/pdb
• 関連するPDBエントリー: 1S3Z 1S5K 1S60
• 分子名称: AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE, (3R,9Z)-17-[(2R,3S,4R,5R,6R)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-3,4-dihydroxytetrahydro-2H-pyran-2-yl]-3-hydroxy-2,2-dimethyl-4,8,15-trioxo-12-thia-5,9,16-triazaheptadec-9-en-1-yl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, NICKEL (II) ION, ... (5 entities in total)
• 機能のキーワード: aminoglycoside, acetyltransferase, drug resistance, bisubstrate inhibitor, transferase
• 由来する生物種: SALMONELLA CHOLERAESUIS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39548.49

構造登録者

Vetting, M.W.,Magalhaes, M.L.,Freiburger, L.,Gao, F.,Auclair, K.,Blanchard, J.S. (登録日: 2007-09-14, 公開日: 2008-01-08, 最終更新日: 2024-05-08)

• 主引用文献: Magalhaes, M.L.,Vetting, M.W.,Gao, F.,Freiburger, L.,Auclair, K.,Blanchard, J.S.; Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase.; Biochemistry, 47:579-, 2008; PubMed: 18095712; DOI: 10.1021/BI701957C

実験手法

X-RAY DIFFRACTION (2 Å)