2VAH
Solution structure of a B-DNA hairpin at low pressure.
Summary for 2VAH
| Entry DOI | 10.2210/pdb2vah/pdb |
| Related | 1DGO 2VAI |
| Descriptor | 5'-D(*AP*GP*GP*AP*TP*CP*CP*TP*UP*TP *TP*GP*GP*AP*TP*CP*CP*T)-3' (1 entity in total) |
| Functional Keywords | dna, b-dna hairpin, pressure |
| Total number of polymer chains | 1 |
| Total formula weight | 5483.54 |
| Authors | Williamson, M.P.,Wilton, D.J.,Ghosh, M.,Chary, K.V.A.,Akasaka, K. (deposition date: 2007-08-31, release date: 2007-09-11, Last modification date: 2024-05-15) |
| Primary citation | Williamson, M.P.,Wilton, D.J.,Ghosh, M.,Chary, K.V.A.,Akasaka, K. Structural Change in a B-DNA Helix with Hydrostatic Pressure Nucleic Acids Res., 36:4032-, 2008 Cited by PubMed Abstract: Study of the effects of pressure on macromolecular structure improves our understanding of the forces governing structure, provides details on the relevance of cavities and packing in structure, increases our understanding of hydration and provides a basis to understand the biology of high-pressure organisms. A study of DNA, in particular, helps us to understand how pressure can affect gene activity. Here we present the first high-resolution experimental study of B-DNA structure at high pressure, using NMR data acquired at pressures up to 200 MPa (2 kbar). The structure of DNA compresses very little, but is distorted so as to widen the minor groove, and to compress hydrogen bonds, with AT pairs compressing more than GC pairs. The minor groove changes are suggested to lead to a compression of the hydration water in the minor groove. PubMed: 18515837DOI: 10.1093/NAR/GKN350 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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