2V8Q

Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP

Summary for 2V8Q

Related2F15
Descriptor5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (5 entities in total)
Functional Keywordsphosphorylation, nucleotide-binding, serine/threonine-protein kinase, kinase, magnesium, cbs domain, transferase
Biological sourceRATTUS NORVEGICUS (RAT)
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Total number of polymer chains3
Total molecular weight66152.37
Authors
Xiao, B.,Heath, R.,Saiu, P.,Leiper, F.C.,Leone, P.,Jing, C.,Walker, P.A.,Haire, L.,Eccleston, J.F.,Davis, C.T.,Martin, S.R.,Carling, D.,Gamblin, S.J. (deposition date: 2007-08-13, release date: 2007-09-25, Last modification date: 2011-07-13)
Primary citation
Xiao, B.,Heath, R.,Saiu, P.,Leiper, F.C.,Leone, P.,Jing, C.,Walker, P.A.,Haire, L.,Eccleston, J.F.,Davis, C.T.,Martin, S.R.,Carling, D.,Gamblin, S.J.
Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449:496-, 2007
PubMed: 17851531 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE06161
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers101.9%8.6%15.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution