2V7R

Crystal structure of a human tRNAGly microhelix at 1.2 Angstrom resolution

2V7R の概要

• エントリーDOI: 10.2210/pdb2v7r/pdb
• 分子名称: HUMAN TRNAGLY MICROHELIX (3 entities in total)
• 機能のキーワード: trna, acceptor stem, glycine, microhelix, identity, hydration, rna
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4432.77

構造登録者

Foerster, C.,Mankowska, M.,Fuerste, J.P.,Perbandt, M.,Betzel, C.,Erdmann, V.A. (登録日: 2007-08-01, 公開日: 2008-03-18, 最終更新日: 2024-05-08)

主引用文献

Foerster, C.,Mankowska, M.,Fuerste, J.P.,Perbandt, M.,Betzel, C.,Erdmann, V.A.
Crystal Structure of a Human Trnagly Microhelix at 1.2 A Resolution.
Biochem.Biophys.Res.Commun., 368:996-, 2008

PubMed Abstract: The tRNA(Gly)/glycyl-tRNA synthetase (GlyRS) system belongs to the so-called 'class II aminoacyl-tRNA synthetase system' in which tRNA identity elements are assured by rather few and simple determinants mostly located in the tRNA acceptor stem. Regarding evolutionary aspects, the tRNA(Gly)/GlyRS system is a special case. There exist two different types of GlyRS, namely an archaebacterial/human type and a eubacterial type reflecting an evolutionary divergence within this system. Here we report the crystal structure of a human tRNA(Gly) acceptor stem microhelix at 1.2A resolution. The local geometric parameters of the microhelix and the water network surrounding the RNA are presented. The structure complements the previously published Escherichia coli tRNA(Gly) aminoacyl stem structure.

PubMed: 18279665
DOI: 10.1016/J.BBRC.2008.01.175

実験手法

X-RAY DIFFRACTION (1.2 Å)