2V61
Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
2V61 の概要
エントリーDOI | 10.2210/pdb2v61/pdb |
関連するPDBエントリー | 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 |
分子名称 | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE, ... (4 entities in total) |
機能のキーワード | fad, membrane, safinamide, flavoprotein, human mao b structure, reversible inhibitor binding, mitochondrion, transmembrane, oxidoreductase, neuroprotection, parkinson's disease |
由来する生物種 | HOMO SAPIENS |
細胞内の位置 | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 119906.12 |
構造登録者 | Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A. (登録日: 2007-07-13, 公開日: 2007-10-16, 最終更新日: 2023-12-13) |
主引用文献 | Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A. Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs. J.Med.Chem., 50:5848-, 2007 Cited by PubMed: 17915852DOI: 10.1021/JM070677Y 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
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