2V60

Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin

2V60 の概要

• エントリーDOI: 10.2210/pdb2v60/pdb
• 関連するPDBエントリー: 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V61
• 分子名称: AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE, ... (4 entities in total)
• 機能のキーワード: fad, membrane, safinamide, flavoprotein, human mao b structure, reversible inhibitor binding, mitochondrion, transmembrane, oxidoreductase, neuroprotection, parkinson's disease
• 由来する生物種: HOMO SAPIENS
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119876.00

構造登録者

Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A. (登録日: 2007-07-12, 公開日: 2007-10-16, 最終更新日: 2024-10-16)

主引用文献

Binda, C.,Wang, J.,Pisani, L.,Caccia, C.,Carotti, A.,Salvati, P.,Edmondson, D.E.,Mattevi, A.
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50:5848-, 2007

PubMed Abstract: Structures of human monoamine oxidase B (MAO B) in complex with safinamide and two coumarin derivatives, all sharing a common benzyloxy substituent, were determined by X-ray crystallography. These compounds competitively inhibit MAO B with Ki values in the 0.1-0.5 microM range that are 30-700-fold lower than those observed with MAO A. The inhibitors bind noncovalently to MAO B, occupying both the entrance and the substrate cavities and showing a similarly oriented benzyloxy substituent.

PubMed: 17915852
DOI: 10.1021/JM070677Y

実験手法

X-RAY DIFFRACTION (2 Å)