2V3F

acid-beta-glucosidase produced in carrot

2V3F の概要

• エントリーDOI: 10.2210/pdb2v3f/pdb
• 関連するPDBエントリー: 1OGS 1Y7V 2F61 2J25 2V3D 2V3E
• 分子名称: GLUCOSYLCERAMIDASE, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: alternative initiation, sphingolipid metabolism, gaucher disease, disease mutation, lipid metabolism, polymorphism, glycoprotein, pharmaceutical, n-butyl-deoxynojirimycin, alternative splicing, acid-beta-glucosidase, membrane, lysosome, hydrolase, glycosidase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116053.03

構造登録者

Shaaltiel, Y.,Bartfeld, D.,Hashmueli, S.,Baum, G.,Brill-Almon, E.,Galili, G.,Dym, O.,Boldin-Adamsky, S.A.,Silman, I.,Sussman, J.L.,Futerman, A.H.,Aviezer, D.,Israel Structural Proteomics Center (ISPC) (登録日: 2007-06-17, 公開日: 2008-04-08, 最終更新日: 2023-12-13)

• 主引用文献: Shaaltiel, Y.,Bartfeld, D.,Hashmueli, S.,Baum, G.,Brill-Almon, E.,Galili, G.,Dym, O.,Boldin-Adamsky, S.A.,Silman, I.,Sussman, J.L.,Futerman, A.H.,Aviezer, D.; Production of Glucocerebrosidase with Terminal Mannose Glycans for Enzyme Replacement Therapy of Gaucher'S Disease Using a Plant Cell System.; Plant Biotechnol.J., 5:579-, 2007; PubMed: 17524049; DOI: 10.1111/J.1467-7652.2007.00263.X

実験手法

X-RAY DIFFRACTION (1.95 Å)