2UWN

Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand.

2UWN の概要

• エントリーDOI: 10.2210/pdb2uwn/pdb
• 関連するPDBエントリー: 1FHC 1HAQ 1HFH 1KOV 2G7I 2JGW 2JGX 2V8E
• 関連するBIRD辞書のPRD_ID: PRD_900013
• 分子名称: HUMAN COMPLEMENT FACTOR H, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: alternative splicing, sucrose octasulphate, age-related macular degeneration, complement alternate pathway, disease mutation, glycosaminoglycan, glycoprotein, innate immunity, immune response, sushi, factor h, complement, polymorphism, immune system
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted: P08603
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22547.79

構造登録者

Prosser, B.E.,Johnson, S.,Roversi, P.,Herbert, A.P.,Blaum, B.S.,Tyrrell, J.,Jowitt, T.A.,Clark, S.J.,Terelli, E.,Uhrin, D.,Barlow, P.N.,Sim, R.B.,Day, A.J.,Lea, S.M. (登録日: 2007-03-22, 公開日: 2007-10-02, 最終更新日: 2023-12-13)

• 主引用文献: Prosser, B.E.,Johnson, S.,Roversi, P.,Herbert, A.P.,Blaum, B.S.,Tyrrell, J.,Jowitt, T.A.,Clark, S.J.,Tarelli, E.,Uhrin, D.,Barlow, P.N.,Sim, R.B.,Day, A.J.,Lea, S.M.; Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.; J.Exp.Med., 204:2277-, 2007; PubMed: 17893204; DOI: 10.1084/JEM.20071069

実験手法

X-RAY DIFFRACTION (2.35 Å)