2UVM
Structure of PKBalpha PH domain in complex with a novel inositol headgroup surrogate, benzene 1,2,3,4-tetrakisphosphate
Summary for 2UVM
Entry DOI | 10.2210/pdb2uvm/pdb |
Related | 1H10 1UNP 1UNQ 1UNR |
Descriptor | RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE, BENZENE-1,2,3,4-TETRAYL TETRAKIS[DIHYDROGEN (PHOSPHATE)], SODIUM ION, ... (4 entities in total) |
Functional Keywords | transferase, glycogen biosynthesis, translation regulation, serine/threonine-protein kinase, phosphoinositide, protein kinase b, glucose metabolism, nuclear protein, cell signalling, phosphorylation, nucleotide-binding, glycogen metabolism, kinase, cancer, inositol, apoptosis, transport, carbohydrate metabolism, ph domain, atp-binding, sugar transport |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: P31749 |
Total number of polymer chains | 1 |
Total formula weight | 15171.61 |
Authors | Komander, D.,Mills, S.J.,Trusselle, M.N.,Safrany, S.T.,van Aalten, D.M.F.,Potter, B.V.L. (deposition date: 2007-03-12, release date: 2007-04-17, Last modification date: 2023-12-13) |
Primary citation | Mills, S.J.,Komander, D.,Trusselle, M.N.,Safrany, S.T.,Van Aalten, D.M.F.,Potter, B.V.L. Novel Inositol Phospholipid Headgroup Surrogate Crystallised in the Pleckstrin Homology Domain of Protein Kinase Balpha. Acs Chem.Biol., 2:242-, 2007 Cited by PubMed: 17432822DOI: 10.1021/CB700019R PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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