2UUH

Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione

Summary for 2UUH

Entry DOI	10.2210/pdb2uuh/pdb
Related	2UUI
Descriptor	LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, DODECYL-ALPHA-D-MALTOSIDE, ... (8 entities in total)
Functional Keywords	membrane protein, leukotriene signalling, lyase, mapeg, human, ltc4s, enzyme, trimer, membrane, leukotriene biosynthesis, eicosanoid, glutathione, transmembrane
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus outer membrane; Multi-pass membrane protein: Q16873
Total number of polymer chains	1
Total formula weight	19979.46
Authors	Martinez Molina, D.,Wetterholm, A.,Kohl, A.,McCarthy, A.A.,Niegowski, D.,Ohlson, E.,Hammarberg, T.,Eshaghi, S.,Haeggstrom, J.Z.,Nordlund, P. (deposition date: 2007-03-02, release date: 2007-07-17, Last modification date: 2011-12-07)
Primary citation	Martinez Molina, D.,Wetterholm, A.,Kohl, A.,Mccarthy, A.A.,Niegowski, D.,Ohlson, E.,Hammarberg, T.,Eshaghi, S.,Haeggstrom, J.Z.,Nordlund, P. Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448:613-, 2007 Cited by PubMed: 17632546 DOI: 10.1038/NATURE06009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation