2UUH

Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione

2UUH の概要

• エントリーDOI: 10.2210/pdb2uuh/pdb
• 関連するPDBエントリー: 2UUI
• 分子名称: LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, DODECYL-ALPHA-D-MALTOSIDE, ... (8 entities in total)
• 機能のキーワード: membrane protein, leukotriene signalling, lyase, mapeg, human, ltc4s, enzyme, trimer, membrane, leukotriene biosynthesis, eicosanoid, glutathione, transmembrane
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus outer membrane; Multi-pass membrane protein: Q16873
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19979.46

構造登録者

Martinez Molina, D.,Wetterholm, A.,Kohl, A.,McCarthy, A.A.,Niegowski, D.,Ohlson, E.,Hammarberg, T.,Eshaghi, S.,Haeggstrom, J.Z.,Nordlund, P. (登録日: 2007-03-02, 公開日: 2007-07-17, 最終更新日: 2011-12-07)

• 主引用文献: Martinez Molina, D.,Wetterholm, A.,Kohl, A.,Mccarthy, A.A.,Niegowski, D.,Ohlson, E.,Hammarberg, T.,Eshaghi, S.,Haeggstrom, J.Z.,Nordlund, P.; Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.; Nature, 448:613-, 2007; PubMed: 17632546; DOI: 10.1038/NATURE06009

実験手法

X-RAY DIFFRACTION (2.15 Å)