2TDD

STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE

2TDD の概要

• エントリーDOI: 10.2210/pdb2tdd/pdb
• 分子名称: THYMIDYLATE SYNTHASE, 5-HYDROXYMETHYLENE-6-HYDROFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: transferase (methyltransferase)
• 由来する生物種: Lactobacillus casei
• 細胞内の位置: Cytoplasm: P00469
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37330.93

構造登録者

Perry, K.M.,Carreras, C.W.,Chang, L.C.,Santi, D.V.,Stroud, R.M. (登録日: 1993-04-05, 公開日: 1993-07-15, 最終更新日: 2024-02-21)

• 主引用文献: Perry, K.M.,Carreras, C.W.,Chang, L.C.,Santi, D.V.,Stroud, R.M.; Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate.; Biochemistry, 32:7116-7125, 1993; PubMed: 8343503; DOI: 10.1021/bi00079a007

実験手法

X-RAY DIFFRACTION (2.7 Å)