2SPC

CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN

2SPC の概要

• エントリーDOI: 10.2210/pdb2spc/pdb
• 分子名称: SPECTRIN (2 entities in total)
• 機能のキーワード: cytoskeleton
• 由来する生物種: Drosophila melanogaster (fruit fly)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24585.46

構造登録者

Yan, Y.,Winograd, E.,Viel, A.,Cronin, T.,Harrison, S.C.,Branton, D. (登録日: 1994-03-01, 公開日: 1994-05-31, 最終更新日: 2024-02-21)

主引用文献

Yan, Y.,Winograd, E.,Viel, A.,Cronin, T.,Harrison, S.C.,Branton, D.
Crystal structure of the repetitive segments of spectrin.
Science, 262:2027-2030, 1993

PubMed Abstract: The elongated proteins of the spectrin family (dystrophin, alpha-actinin, and spectrin) contain tandemly repeated segments and form resilient cellular meshworks by cross-linking actin filaments. The structure of one of the repetitive segments of alpha-spectrin was determined at a 1.8 angstrom resolution. A segment consists of a three-helix bundle. A model of the interface between two tandem segments suggests that hydrophobic interactions between segments may constrain intersegment flexibility. The helix side chain interactions explain how mutations that are known to produce hemolytic anemias disrupt spectrin associations that sustain the integrity of the erythrocyte membrane.

PubMed: 8266097

実験手法

X-RAY DIFFRACTION (1.8 Å)