2RQB

Solution structure of MDA5 CTD

2RQB の概要

• エントリーDOI: 10.2210/pdb2rqb/pdb
• 分子名称: Interferon-induced helicase C domain-containing protein 1, ZINC ION (2 entities in total)
• 機能のキーワード: rna binding protein, hydrolase, alternative splicing, antiviral defense, atp-binding, cytoplasm, diabetes mellitus, helicase, host-virus interaction, immune response, innate immunity, nucleotide-binding, nucleus, phosphoprotein, polymorphism, rna-binding
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q9BYX4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15568.51

構造登録者

Takahasi, K.,Kumeta, H.,Tsuduki, N.,Narita, R.,Shigemoto, T.,Hirai, R.,Yoneyama, M.,Horiuchi, M.,Ogura, K.,Fujita, T.,Fuyuhiko, I. (登録日: 2009-03-17, 公開日: 2009-05-05, 最終更新日: 2022-03-16)

• 主引用文献: Takahasi, K.,Kumeta, H.,Tsuduki, N.,Narita, R.,Shigemoto, T.,Hirai, R.,Yoneyama, M.,Horiuchi, M.,Ogura, K.,Fujita, T.,Inagaki, F.; Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains: IDENTIFICATION OF THE RNA RECOGNITION LOOP IN RIG-I-LIKE RECEPTORS; J.Biol.Chem., 284:17465-17474, 2009; PubMed: 19380577; DOI: 10.1074/jbc.M109.007179

実験手法

SOLUTION NMR