2ROC

Solution structure of Mcl-1 Complexed with Puma

2ROC の概要

• エントリーDOI: 10.2210/pdb2roc/pdb
• 関連するPDBエントリー: 1WSX 2JM6 2ROD
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-binding component 3 (2 entities in total)
• 機能のキーワード: mcl-1, bcl-2, apoptosis, puma, bh3-only, cytoplasm, developmental protein, differentiation, membrane, mitochondrion, nucleus, phosphoprotein, transmembrane, ubl conjugation
• 由来する生物種: Mus musculus (Mouse); 詳細
• 細胞内の位置: Membrane; Single-pass membrane protein (By similarity): P97287; Mitochondrion: Q99ML1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21585.33

構造登録者

Day, C.L.,Smits, C.,Fan, F.C.,Lee, E.F.,Fairlie, W.D.,Hinds, M.G. (登録日: 2008-03-17, 公開日: 2008-07-08, 最終更新日: 2021-11-10)

• 主引用文献: Day, C.L.,Smits, C.,Fan, F.C.,Lee, E.F.,Fairlie, W.D.,Hinds, M.G.; Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1; J.Mol.Biol., 380:958-971, 2008; PubMed: 18589438; DOI: 10.1016/j.jmb.2008.05.071

実験手法

SOLUTION NMR