2RMX
Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Summary for 2RMX
Entry DOI | 10.2210/pdb2rmx/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 6, NKG2-A/NKG2-B type II integral membrane protein (2 entities in total) |
Functional Keywords | sh2 domain, protein-peptide complex, phosphorylated peptide recognition, phosphotyrosine binding domain, signal transduction, alternative splicing, cytoplasm, hydrolase, nucleus, phosphoprotein, protein phosphatase, glycoprotein, lectin, membrane, receptor, signal-anchor, transmembrane, signaling protein, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P29350 Membrane; Single-pass type II membrane protein: P26715 |
Total number of polymer chains | 2 |
Total formula weight | 14364.83 |
Authors | Kasai, T.,Koshiba, S.,Inoue, M.,Kigawa, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-11-30, release date: 2008-12-02, Last modification date: 2022-03-16) |
Primary citation | Koshiba, S.,Kasai, T.,Sato, M.,Tomizawa, T.,Motoda, Y.,Tochio, N.,Kobayashi, N.,Harada, T.,Inoue, M.,Tanaka, A.,Kigawa, T.,Yokoyama, S. Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1 To be Published, |
Experimental method | SOLUTION NMR |
Structure validation
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