2RLQ

NMR structure of CCP modules 2-3 of complement factor H

2RLQ の概要

• エントリーDOI: 10.2210/pdb2rlq/pdb
• 関連するPDBエントリー: 2BZM 2JGW 2JGX 2RLP
• 分子名称: Complement factor H (1 entity in total)
• 機能のキーワード: complement, factor h, age-related macular degeneration, immune system, cofactor activity, alternative splicing, complement alternate pathway, disease mutation, glycoprotein, immune response, innate immunity, polymorphism, secreted, sushi
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P08603
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14183.70

構造登録者

Hocking, H.G.,Herbert, A.P.,Pangburn, M.K.,Kavanagh, D.,Barlow, P.N.,Uhrin, D. (登録日: 2007-07-29, 公開日: 2008-02-19, 最終更新日: 2022-03-16)

• 主引用文献: Hocking, H.G.,Herbert, A.P.,Kavanagh, D.,Soares, D.C.,Ferreira, V.P.,Pangburn, M.K.,Uhrin, D.,Barlow, P.N.; Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.; J.Biol.Chem., 283:9475-9487, 2008; PubMed: 18252712; DOI: 10.1074/jbc.M709587200

実験手法

SOLUTION NMR