2RL5

Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor

2RL5 の概要

• エントリーDOI: 10.2210/pdb2rl5/pdb
• 分子名称: Vascular endothelial growth factor receptor 2, N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphorylation, polymorphism, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36776.51

構造登録者

Whittington, D.A.,Long, A.M.,Rose, P.,Zhao, H. (登録日: 2007-10-18, 公開日: 2008-04-08, 最終更新日: 2024-02-21)

• 主引用文献: La, D.S.,Belzile, J.,Bready, J.V.,Coxon, A.,Demelfi, T.,Doerr, N.,Estrada, J.,Flynn, J.C.,Flynn, S.R.,Graceffa, R.F.,Harriman, S.P.,Larrow, J.F.,Long, A.M.,Martin, M.W.,Morrison, M.J.,Patel, V.F.,Roveto, P.M.,Wang, L.,Weiss, M.M.,Whittington, D.A.,Teffera, Y.,Zhao, Z.,Polverino, A.J.,Harmange, J.C.; Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis.; J.Med.Chem., 51:1695-1705, 2008; PubMed: 18311900; DOI: 10.1021/jm701129j

実験手法

X-RAY DIFFRACTION (2.65 Å)