2RKF
HIV-1 PR resistant mutant + LPV
Summary for 2RKF
Entry DOI | 10.2210/pdb2rkf/pdb |
Descriptor | PROTEASE RETROPEPSIN, SULFATE ION, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (5 entities in total) |
Functional Keywords | resistence, insertion, hydrolase |
Biological source | human immunodeficiency virus 1 (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22572.43 |
Authors | Rezacova, P.,Brynda, J.,Kozisek, M.,Saskova, K.G.,Konvalinka, J. (deposition date: 2007-10-16, release date: 2008-08-05, Last modification date: 2023-08-30) |
Primary citation | Kozisek, M.,Saskova, K.G.,Rezacova, P.,Brynda, J.,van Maarseveen, N.M.,De Jong, D.,Boucher, C.A.,Kagan, R.M.,Nijhuis, M.,Konvalinka, J. Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region J.Virol., 82:5869-5878, 2008 Cited by PubMed: 18400858DOI: 10.1128/JVI.02325-07 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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